buy 2MAP (2-Methyl-AP237)

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  • Product Name: 2MAP
  • Active Ingredients: 2-Methyl-AP237
  • Amount: 1 Gram
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Description

2-METHYL-AP-237 is an opioid analgesic drug that was widely used in China to treat pain in cancer patients as of 1986.It is one of the most potent compound among a series of analgesic acyl piperazines compounds first synthesized and reported in Japan in the 1970s.buy 2MAP (2-Methyl-AP237)

2-METHYL-AP-237 has analgesic potency comparable to that of morphine but with a relatively higher therapeutic index.

The drug were initially claimed to be a non-narcotic analgesic. However, subsequent studies have shown 2-METHYL-AP-237 and similar acyl piperazines to be potent and selective agonists of μ-opioid receptor (MOR) with relatively low affinity for the δ-opioid receptor and the κ-opioid receptor. In accordance with these studies, results from the intravenous self-administration experiments in rats showed that 2-METHYL-AP-237 has a marked reinforcing effect with tolerance and dependence quickly developing. In addition, the morphine antagonist naloxone reverses the effect of AP-237 and precipitates withdrawal symptoms in 2-METHYL-AP-237 treated rats further indicating a mechanism of analgesia mediated via selective agonist activity at μ-opioid receptors.buy 2MAP (2-Methyl-AP237).buy 2MAP (2-Methyl-AP237)

  • Synonyms: 2MAP
  • Formal Name: 1-[2-methyl-4-(3-phenyl-2-propen-1-yl)-1-piperazinyl]-1-butanone, monohydrochloride
  • CAS Number: 98608-59-4
  • Molecular Formula: C18H26N2O
  • Molecular Weight: 257.7
  • Purity: ≥99%
  • Formulation: A crystalline solid

Additional information

Quantity

3g, 5g, 10g

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